封面 家蚕功能基因组研究（上册） 封面 书名页 版权页 夏庆友 向仲怀 钟伯雄 冯启理 崔红娟 周泽扬 李胜 黄勇平 鲁成 沈卫德 张耀洲 王俊 曹阳 郭锡杰 何宁佳 张芝利 陈杰 喻子牛 张家骅 杨公社 徐卫华 周丛照 李龙 鲁兴萌 编写说明 前言 目录页 第一章 家蚕丝蛋白合成机制与蚕丝生物材料 The gene expression profile of Bombyx mori silk gland 家蚕丝腺基因表达谱的研究 Studies on middle and posterior silk glands of silkworm(Bombyx mori)using two-dimensional electrophoresis and mass spectrometry 利用双向电泳和质谱分析技术鉴定家蚕中部丝腺与后部丝腺蛋白质组学差异 Expression profiling and regulation of genes related to silkworm posterior silk gland development and fibroin synthesis 家蚕后部丝腺发育和丝素蛋白合成相关基因的表达及调控 Comparative proteomic and phosphoproteomic analysis of the silkworm(Bombyx mori)posterior silk gland under high temperature treatment 高温胁迫下家蚕后部丝腺差异蛋白质组和磷酸化蛋白质组学分析 Shotgun proteomic analysis of the Bombyx mori anterior silk gland:An insight into the biosynthetic fiber spinning process 鸟枪法分析家蚕前部丝腺蛋白组学：深入了解生物合成纤维纺丝过程 Quantitative proteomic and transcriptomic analyses of molecular mechanisms associated with low silk production in silkworm Bombyx mori 定量蛋白质组学和转录组学分析家蚕低产丝量的分子机制 Transcriptomic analysis of differentially expressed genes in the Ras1^(CA)-overexpressed and wildtype posterior silk glands 超表达Ras1CA家蚕后部丝腺转录组变化研究 Transcriptomic analysis of the anterior silk gland in the domestic silkworm(Bombyx mori):Insight into the mechanism of silk formation and spinning 家蚕前部丝腺的转录组分析——蚕丝形成与吐丝机理的探讨 Comparative proteomic analysis of the silkworm middle silk gland reveals the importance of ribosome biogenesis in silk protein production 比较蛋白质组学分析家蚕中部丝腺揭示核糖体生成对丝蛋白生产的重要性 Analyses of the molecular mechanisms associated with silk production in silkworm by iTRAQbased proteomics and RNA-sequencing-based transcriptomics 利用基于iTRAQ的蛋白质组学和基于RNA测序的转录组学研究蚕丝产量的分子机制 Phosphoproteomic analysis of the posterior silk gland of Bombyx mori provides novel insight into phosphorylation regulating the silk production 家蚕后部丝腺磷酸化蛋白质组分析揭示蛋白磷酸化调控蚕丝产量机制 Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori 家蚕丝腺腔内蛋白质组学动力学分析 Comparative proteomic analysis of posterior silk glands of wild and domesticated silkworms reveals functional evolution during domestication 比较蛋白质组学分析野蚕和家蚕后部丝腺揭示其在驯养过程中的功能进化 GC/MS-based metabolomic studies reveal key roles of glycine in regulating silk synthesis in silkworm,Bombyx mori 基于GC-MS的代谢组学研究揭示甘氨酸在蚕丝合成中的重要作用 DNA replication events during larval silk gland development in the silkworm,Bombyx mori 家蚕幼虫丝腺发育过程中的DNA复制 Autophagy,apoptosis,and ecdysis-related gene expression in the silk gland of the silkworm(Bombyx mori)during metamorphosis 家蚕变态期丝腺中自噬、凋亡和蜕皮相关基因的表达分析 Proteomic analysis of silk gland programmed cell death during metamorphosis of the silkworm Bombyx mori 家蚕变态过程中丝腺程序性细胞死亡的蛋白组学分析 Role of BmDredd during apoptosis of silk gland in silkworm,Bombyx mori 家蚕变态期丝腺凋亡过程中BmDredd基因的作用 Ras1 ^CA)-upregulated bcpi inhibits cathepsin activity to prevent tissue destruction of the Bombyx posterior silk gland Ras1^(CA)诱导的bcpi蛋白抑制组织蛋白酶活性从而阻止家蚕后部丝腺组织解体 A juvenile hormone transcription factor Bmdimm-fibroin H chain pathway is involved in the synthesis of silk protein in silkworm,Bombyx mori 保幼激素转录因子Bmdimm-丝素重链通路参与家蚕丝蛋白的合成 Transcription factor Bmsage plays a crucial role in silk gland generation in silkworm,Bombyx mori 转录因子Bmsage在家蚕丝腺发育中发挥关键作用 Multiprotein bridging factor 2 regulates the expression of the fibroin heavy chain gene by interacting with Bmdimmed in the silkworm Bombyx mori 多蛋白桥连因子2通过与转录因子Bmdimm互作调控丝素重链基因的表达 Biochemical characterization and functional analysis of the POU transcription factor POU-M2 of Bombyx mori 家蚕POU家族转录因子POU-M2的生化表征和功能分析 Structures of an all-αprotein running along the DNA major groove DNA大沟的全α类蛋白的结构解析 Effect of BBX-B8 overexpression on development,body weight,silk protein synthesis and egg diapause of Bombyx mori 过表达BBX-B8对家蚕发育、体重增加、丝蛋白合成和卵滞育的影响 Comparative proteomics reveal diverse functions and dynamic changes of Bombyx mori silk proteins spun from different development stages 比较蛋白质组学揭示不同发育阶段家蚕纺出的蚕丝蛋白的不同功能和动态变化 Comparative proteome analysis of multi-layer cocoon of the silkworm,Bombyx mori 家蚕不同茧层的比较蛋白质组学分析 Protease inhibitors in Bombyx mori silk might participate in protecting the pupating larva from microbial infection 蚕丝中的蛋白酶抑制剂可能参与保护化蛹的幼虫免于病原物的感染 Proteins in the cocoon of silkworm inhibit the growth of Beauveria bassiana 蚕茧中的蛋白质抑制白僵菌的生长 Structure,evolution,and expression of antimicrobial silk proteins,seroins in Lepidoptera 鳞翅目昆虫抗菌丝蛋白Seroins的结构、进化与表达分析 Modifying the mechanical properties of silk fiber by genetically disrupting the ionic environment for silk formation 通过遗传改造家蚕丝纤维形成的离子环境以改良蚕丝纤维的力学性能 Construction of transgenic silkworm spinning antibacterial silk with fluorescence 绿色荧光抗菌蚕丝的转基因家蚕的制备 Characterization of transgenic silkworm yielded biomaterials with calcium-binding activity 生产钙结合活性生物材料的转基因家蚕的表征 Synthesis of silk fibroin-insulin bioconjugates and their characterization and activities in vivo 蚕丝丝素-胰岛素生物结合物的合成及其理化性能与体内的生物活性 Formation of silk fibroin nanoparticles in water-miscible organic solvent and their characterization 水溶性有机溶剂中丝素纳米颗粒的形成及其特性 Preparation of silk fibroin nanoparticles and their application to immobilization of L-asparaginase 丝素纳米颗粒的制备及应用于L-天冬酰胺酶的固定化 Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system 胰岛素-丝素纳米颗粒生物结合物的合成及其药物递送系统的体外评估 Silk sericin-insulin bioconjugates:Synthesis,characterization and biological activity 蚕丝丝胶肽-胰岛素生物结合物：合成、特性及其生物活性 Preparation and characterization of silver nanoparticles composited on polyelectrolyte film coated sericin gel for enhanced antibacterial application 制备和表征纳米银修饰的聚电解质薄膜包被的丝胶凝胶及其强力抗菌应用 Characterization of silver nanoparticle in situ synthesis on porous sericin gel for antibacterial application 原位制备纳米银杂化的丝胶多孔凝胶及其抗菌性能 第二章 家蚕变态发育机制研究 The synthesis,transportation and degradation of BmLP3 and BmLP7,two highly homologous Bombyx mori 30K proteins 两种高度同源的家蚕30K蛋白：BmLP3和BmLP7的合成、转运和降解 Serine protease P-IIc is responsible for the digestion of yolk proteins at the late stage of silkworm embryogenesis 丝氨酸蛋白酶P-IIc参与家蚕胚胎发育后期卵黄蛋白的降解 Identification and function of Abdominal-A in the silkworm,Bombyx mori 家蚕Abdominal-A的鉴定和功能分析 Identification and expression of the achaete-scute complex in the silkworm,Bombyx mori 家蚕achaete-scute复合物的鉴定及其表达谱分析 Cathepsin B protease is required for metamorphism in silkworm,Bombyx mori 组织蛋白酶B在家蚕变态发育过程中的功能研究 Hedgehog signaling pathway regulated the target genes for adipogenesis in silkworm Bombyx mori Hedgehog信号通路调控家蚕脂肪体形成的靶基因研究 BmPLA2 containing conserved domain WD40 affects the metabolic functions of fat body tissue in silkworm,Bombyx mori 含WD40保守结构域的BmPLA2影响家蚕的脂肪体代谢 Identification and characterization of novel chitin-binding proteins from the larval cuticle of silkworm,Bombyx mori 家蚕幼虫表皮中几丁质结合蛋白的鉴定与分析 Identification and molecular characterization of a chitin deacetylase from Bombyx mori peritrophic membrane 家蚕围食膜几丁质脱乙酰基酶的鉴定和分子表征 BmRobo2/3 is required for axon guidance in the silkworm Bombyx mori 家蚕轴突引导需要BmRobo2/3 BmRobo1a and BmRobo1b control axon repulsion in the silkworm Bombyx mori 家蚕BmRobo1a和BmRobo1b控制轴突排斥 Bmaly is an important factor in meiotic progression and spermatid differentiation in Bombyx mori(Lepidoptera:Bombycidae) 家蚕（鳞翅目：蚕蛾科）Bmaly基因在减数分裂进程和精子分化中起关键作用 Lysine acetylation stabilizes SP2 protein in the silkworm,Bombyx mori 家蚕赖氨酸乙酰化修饰可以提高SP2蛋白稳定性 Bmovo-1 regulates ovary size in the silkworm,Bombyx mori Bmovo-1调节家蚕卵巢的大小 RNA interference-mediated silencing of the bursicon gene induces defects in wing expansion of silkworm RNA干扰介导的bursicon基因沉默诱导家蚕翅伸展缺陷 Molecular characterization and immunohistochemical localization of a novel troponin C during silkworm development 一种新的家蚕肌钙蛋白的分子鉴定与免疫组化定位分析 Systematic cloning and analysis of autophagy-related genes from the silkworm Bombyx mori 家蚕自噬相关基因的系统克隆和分析 Influence of RNAi knockdown for E-complex genes on the silkworm proleg development RNA干扰敲除E复合体基因对家蚕腹足发育的影响 Cloning and characterization of Bmrunt from the silkworm Bombyx mori during embryonic development 家蚕胚胎发育时期Bmrunt的克隆和鉴定 Identification and characterization of two chitin-binding proteins from the peritrophic membrane of the silkworm,Bombyx mori L. 家蚕围食膜两种几丁质结合蛋白的鉴定及表征 Cloning and expression pattern of 3-dehydroecdysone 3β-reductase(3DE 3β-reductase)from the silkworm,Bombyx mori L. 家蚕3-脱氢蜕皮激素-3β还原酶基因的克隆及其在家蚕不同发育时期和不同组织中的表达模式 Expression of open reading frames in silkworm pupal cDNA library 蚕蛹cDNA文库中开放阅读框的表达 Spatiotemporal expression profile of the Pumilio gene in the embryonic development of silkworm 家蚕胚胎发育中Pumilio基因的时空表达谱 Cloning and expression characteristics of the Notch-associated gene BmE(spl)mγfrom silkworm,Bombyx mori 家蚕Notch相关基因BmE（spl）mγ的克隆和表达分析 Homeodomain POU and Abd-A proteins regulate the transcription of pupal genes during metamorphosis of the silkworm,Bombyx mori 同源域类转录因子POU和Abd-A蛋白调控家蚕变态发育过程中蛹期基因的转录 Autophagy and its physiological relevance in arthropods:Current knowledge and perspectives 关于细胞自噬及其同节肢动物生理关联性的当前认知和观点 20-hydroxyecdysone upregulates Atg genes to induce autophagy in the Bombyx fat body 20-羟基蜕皮酮通过上调家蚕脂肪体中自噬相关基因Atg的表达诱导自噬的发生 BmATG5 and BmATG6 mediate apoptosis following autophagy induced by 20-hydroxyecdysone or starvation 家蚕BmATG5、BmATG6蛋白介导蜕皮激素或饥饿诱导的细胞自噬后的细胞凋亡 Functional analysis of insect molting fluid proteins on the protection and regulation of ecdysis 昆虫蜕皮液蛋白在保护和调控蜕皮时的功能分析 The homeodomain transcription factors Antennapedia and POU-M2 regulate the transcription of the steroidogenic enzyme gene Phantom in the silkworm 家蚕同源结构域转录因子Antennapedia（Antp）和POU-M2调控蜕皮激素合成酶基因Phantom的转录 20-hydroxyecdysone(20E)primary response gene E93 modulates 20E signaling to promote Bombyx larval-pupal metamorphosis 20E的初级应答基因E93通过调节20E信号参与调控家蚕幼虫-蛹变态发育 20-Hydroxyecdysone(20E)primary response gene E75 isoforms mediate steroidogenesis autoregulation and regulate developmental timing in Bombyx 家蚕中20E的初级应答基因E75三个异构体调控20E合成的自我调节和发育时序的机制 BmBR-C Z4 is an upstream regulatory factor of BmPOUM2 controlling the pupal specific expression of BmWCP4 in the silkworm,Bombyx mori 家蚕转录因子BmBR-C Z4通过BmPOUM2来调控翅原基表皮蛋白基因BmWCP4在蛹期的专一性表达 Transcription factors BmPOUM2 and BmβFTZ-F1 are involved in regulation of the expression of the wing cuticle protein gene BmWCP4 in the silkworm,Bombyx mori 家蚕转录因子BmPOUM2和BmβFTZ-F1参与调控家蚕翅原基表皮蛋白基因BmWCP4的表达 The silkworm homolog of Methoprene tolerant(Met)gene reveals sequence conservation but function divergence 家蚕Met基因的同源性揭示了序列上的保守性和功能上的差异性 Analysis of expression and chitin-binding activity of the wing disc cuticle protein BmWCP4 in the silkworm,Bombyx mori 家蚕翅原基表皮蛋白BmWCP4的表达与几丁质结合活性的分析 Autophagy precedes apoptosis during the remodeling of silkworm larval midgut 家蚕幼虫中肠重塑过程中细胞自噬先于细胞凋亡 The Broad Complex isoform 2(BrC-Z2)transcriptional factor plays a critical role in vitellogenin transcription in the silkworm Bombyx mori 转录因子BrC-Z2在家蚕卵黄原蛋白（Vg）基因的转录过程中扮演重要角色 Transcriptomic analysis of developmental features of Bombyx mori wing disc during metamorphosis 家蚕变态发育时期翅原基的转录组学分析 Bombyx E75 isoforms display stage-and tissue-specific responses to 20-hydroxyecdysone 家蚕E75异构体展现出对20-蜕皮激素的时期组织特异性响应 Transcription factor SGF1 is critical for the neurodevelopment in the silkworm,Bombyx mori SGF1是家蚕神经发育过程中关键的转录因子 SAGE tag based cDNA microarray analysis during larval to pupal development and isolation of novel cDNAs in Bombyx mori 利用基于SAGE标签的芯片技术分析并分离家蚕从幼虫到蛹发育过程的新cDNA Ecdysone receptor(EcR)is involved in the transcription of cell cycle genes in the silkworm 家蚕蜕皮激素受体（EcR）参与细胞周期基因转录 Antennapedia is involved in the development of thoracic legs and segmentation in the silkworm,Bombyx mori Antennapedia参与家蚕胸足的发育及体节的分化 MET is required for the maximal action of 20-hydroxyecdysone during Bombyx metamorphosis MET蛋白是家蚕变态发育过程中20E最大程度发挥功能的必需蛋白 Coevolution of axon guidance molecule Slit and its receptor Robo 轴突导向因子Slit及其受体Robo的共同进化 Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1 家蚕转录因子BR-C通过与RACK1的相互作用来完成其核转位 Preliminary characterization of a death-related gene in silkworm Bombyx mori 家蚕中死亡相关基因特性的初步研究 Transcriptional regulation of the gene for prothoracicotropic hormone in the silkworm,Bombyx mori 家蚕促前胸腺激素的转录调控 Phenol oxidase is a necessary enzyme for the silkworm molting which is regulated by molting hormone 酚氧化酶是受蜕皮激素调节的家蚕蜕皮必需酶 Expression and functions of dopa decarboxylase in the silkworm,Bombyx mori was regulated by molting hormone 由蜕皮激素调控的家蚕多巴脱羧酶的表达和功能研究 Molecular cloning and expression characterization of translationally controlled tumor protein in silkworm pupae 蚕蛹翻译调控肿瘤蛋白的分子克隆及表达特征研究 Molecular cloning and transcription expression of 3-dehydroecdysone 3α-reductase(3-DE 3α-reductase)in the different tissues and the developing stage from the silkworm,Bombyx mori L. 家蚕3-DE 3α-还原酶的克隆及其在家蚕不同发育时期和不同组织中的转录表达分析 Characterization of adaptor protein complex-1 in the silkworm,Bombyx mori 家蚕衔接蛋白复合物1（AP-1）的表征 Cloning and characterization of the Bombyx mori ecdysone oxidase 家蚕蜕皮激素氧化酶的克隆与分析 RNAiknockdown of BmRab3 led to larva and pupa lethality in silkworm Bombyx mori L. RNAi干涉家蚕BmRab3导致家蚕幼虫和蛹致死 Structure of autophagy-related protein Atg8 from the silkworm Bombyx mori 家蚕自噬相关蛋白Atg8的结构分析 Microarray analysis of the juvenile hormone response in larval integument of the silkworm,Bombyx mori 家蚕幼虫表皮保幼激素应答的芯片分析 Expression pattern of enzymes related to juvenile hormone metabolism in the silkworm,Bombyx mori L. 家蚕保幼激素代谢相关酶的表达模式 Molecular cloning and characterization of hatching enzyme-like gene in the silkworm,Bombyx mori 家蚕类孵化酶基因的分子克隆和鉴定 Molecular cloning and characterization of hatching enzyme-like gene II(BmHELII)in the silkworm,Bombyx mori 家蚕类孵化酶基因II（BmHELII）的分子克隆及特征分析 第三章 家蚕免疫机制研究 Structures,regulatory regions,and inductive expression patterns of antimicrobial peptide genes in the silkworm Bombyx mori 家蚕抗菌肽基因的结构、调控区域以及诱导表达模式 Proteolytic activation of pro-sp鋞zle is required for the induced transcription of antimicrobial peptide genes in lepidopteran insects 裂解活化的pro-sp?tzle蛋白是鳞翅目昆虫抗菌肽基因诱导上调表达的必需条件 Smt3 is required for the immune response of silkworm,Bombyx mori Smt3基因为家蚕免疫反应所必需的基因 Gloverins of the silkworm Bombyx mori:structural and binding properties and activities 家蚕葛佬素的结构、结合特性和活性研究 Translationally controlled tumor protein,a dual functional protein involved in the immune response of the silkworm,Bombyx mori 翻译调控肿瘤蛋白作为双功能蛋白参与家蚕免疫反应 Cloning and characterization of Bombyx mori PP-BP,a gene induced by viral infection 家蚕瘫痪肽结合蛋白基因克隆与分析 Molecular cloning and functional characterization of the dual oxidase(BmDuox)gene from the Silkworm Bombyx mori 家蚕双重氧化酶BmDuox基因的分子克隆和功能特性 Activity of fusion prophenoloxidase-GFP and its potential applications for innate immunity study PPO-GFP融合蛋白的活性及其在昆虫先天免疫研究中的潜在应用 Paralytic peptide activates insect humoral immune response via epidermal growth factor receptor 麻痹肽通过表皮生长因子受体激活昆虫体液免疫反应 A Fas associated factor negatively regulates anti-bacterial immunity by promoting Relish degradation in Bombyx mori Fas相关因子通过降解Relish负调控家蚕抗菌免疫反应 Overexpression of Bm65 correlates with reduced susceptibility to inactivation by UV light Bm65的过量表达与紫外线灭活后的敏感性降低有关 Characterization of the Bombyx mori Cecropin A1 promoter regulated by IMD pathway 受IMD通路调节的家蚕CecropinA1启动子分析 Functional divergence of six isoforms of antifungal peptide Drosomycin in Drosophila melanogaster 黑腹果蝇中抗真菌肽Drosomycin的六种异构体的功能分化 Inducing and isolation of antibacterial peptides from oriental fruit fly,Bactrocera dorsalis Hendel 桔实蝇中抗菌肽的诱导和分离 A silkworm hemolymph protein is a prophenoloxidase activation blocker 家蚕血淋巴蛋白是一种酚氧化酶活化阻断剂 Molecular cloning,characterization and expression analysis of Cathepsin O in silkworm Bombyx mori related to bacterial response 家蚕细菌应答相关基因Cathepsin O的分子克隆、鉴定和表达分析 Molecular cloning of Bombyx mori cytochrome P-450 gene and its involvement in fluoride resistance 家蚕细胞色素P-450基因的分子克隆及其在抵抗氟化物中毒中的作用 A short-type peptidoglycan recognition protein from the silkworm:expression,characterization and involvement in the prophenoloxidase activation pathway 家蚕肽聚糖识别蛋白PGRP-S5的表达纯化及其在酚氧化酶级联反应中的作用研究 Expression and localization of silkworm adaptor protein complex-1 subunits,which were downregulated post baculovirus infection 杆状病毒感染后下调表达的家蚕衔接蛋白复合物-1的亚基分子的表达和定位 Characterization of CIb1 gene promoter from silkworm,Bombyx mori 家蚕CIb1基因启动子的特征分析 Molecular cloning,expression and characterization of Bmserpin-2 gene from Bombyx mori 家蚕Bmserpin-2基因的分子克隆、表达及特征分析 Expression,purification and characterization of a three-domain Kazal-type inhibitor from silkworm pupae(Bombyx mori) 家蚕蛹中含有三个结构域的Kazal型蛋白酶抑制剂的表达、纯化和表征 Glutathione S-transferases from the larval gut of the silkworm Bombyx mori:cDNA cloning,gene structure,expression and distribution 家蚕幼虫肠道谷胱甘肽S转移酶的克隆、基因结构、表达与分布 Purification and biochemical characterization of a novel glutathioneS-transferase of the silkworm,Bombyx mori 家蚕新型谷胱甘肽S转移酶的纯化和生化特征分析 Identification,genomic organization and expression pattern of glutathione S-transferase in the silkworm,Bombyx mori 家蚕谷胱甘肽S转移酶基因的克隆、序列分析及其表达模式 Identification of a novel spore wall protein(SWP26)from microsporidia Nosema bombycis 从家蚕微孢子虫中鉴定一种新的孢壁蛋白（SWP26） SWP25,a novel protein associated with the Nosema bombycis endospore SWP25，一个新的家蚕微孢子虫内壁相关蛋白质 Protein profile of Nomuraea rileyi spore isolated from infected silkworm 侵染家蚕的Nomuraearileyi孢子的蛋白质图谱 Characterization of a transcriptionally active Tc1-like transposon in the microsporidian Nosema bombycis 微孢子虫中的转录活性Tc1样转座子的特征分析 Identification of NbME MITE families:potential molecular markers in the microsporidia Nosema bombycis 鉴定NbMEMITE家族：家蚕微孢子虫潜在的分子标记物 Characterization of a subtilisin-like protease with apical localization from microsporidian Nosema bombycis 家蚕微孢子虫的一种具有顶端定位特征的类枯草杆菌蛋白酶NbSLP1的鉴定 Identification of a novel chitin-binding spore wall protein(NbSWP12)with a BAR-2 domain from Nosema bombycis(microsporidia) 家蚕微孢子虫的一种具有BAR-2功能域的几丁质结合孢壁蛋白（NbSWP12）的鉴定 Identification of a protein interacting with the spore wall protein SWP26 of Nosema bombycis in a cultured BmN cell line of silkworm 家蚕微孢子虫孢壁蛋白——SWP26与家蚕BmN细胞系互作蛋白的筛选与鉴定 Molecular characteristics of the alpha-and beta-tubulin genes of Nosema philosamiae 蓖麻蚕微孢子虫α-与β-微管蛋白的分子特征 NbHSWP11,a microsporidia Nosema bombycis protein,localizing in the spore wall and membranes,reduces spore adherence to host cell BmE 定位于孢壁和孢膜上的家蚕微孢子虫蛋白NbHSWP11减弱孢子对宿主细胞BmE的黏附 Morphological and molecular studies of Vairimorpha necatrix BM,a new strain of the microsporidium V.necatrix(microsporidia,burenellidae)recorded in the silkworm,Bombyx mori 一株家蚕中新分离的纳卡变形微孢子虫的形态学以及分子研究 Nosema sp.PM-1,a new isolate of microsporidian from infected Papilio machaon Linnaeus,based on ultrastructure and molecular identification 通过超结构和分子鉴定从被感染的金凤蝶中分离到新型微孢子虫Nosemasp.PM-1 Interaction and assembly of two novel proteins in the spore wall of the microsporidian species Nosema bombycis and their roles in adherence to and infection of host cells 两个新型家蚕微孢子虫孢壁蛋白的互作、组装及其在宿主细胞感染和黏附中的作用 Characterization of a novel spore wall protein NbSWP16 with proline-rich tandem repeats from Nosema bombycis(microsporidia) 一种新的富含脯氨酸串联重复序列的家蚕微孢子虫孢壁蛋白NbSWP16的鉴定 Characterization of a novel otubain-like protease with deubiquitination activity from Nosema bombycis(Microsporidia) 一种新的家蚕微孢子虫类otubain蛋白酶的鉴定 Characterization of the first fungal glycosyl hydrolase family 19 chitinase(NbchiA)from Nosema bombycis(Nb) 家蚕微孢子虫糖基水解酶第19家族的几丁质酶（NbchiA）的鉴定 Exogenous gene can be integrated into Nosema bombycis genome by mediating with a nontransposon vector 非转座子载体可介导外源基因整合进入家蚕微孢子虫基因组 Multiple rDNA units distributed on all chromosomes of Nosema bombycis 家蚕微孢子虫全基因组中分布的若干核糖体DNA（rDNA）单元 Intraspecific polymorphism of rDNA among five Nosema bombycis isolates from different geographic regions in China 来自中国五个不同地域的家蚕微孢子虫rDNA序列种内多态性研究 Development of an approach to analyze the interaction between Nosema bombycis(microsporidia)deproteinated chitin spore coats and spore wall proteins 家蚕微孢子虫脱蛋白几丁质孢壳和孢壁蛋白相互作用的分析方法的建立 Bm59 is an early gene,but is unessential for the propagation and assembly of Bombyx mori nucleopolyhedrovirus 早期基因Bm59不是家蚕核型多角体病毒BmNPV传播和组装的必需基因 Characterization of Bombyx mori nucleopolyhedrovirus with a knockout of Bm17 敲除家蚕核型多角体病毒基因Bm17的特性分析 BM61 of Bombyx mori nucleopolyhedrovirus:its involvement in the egress of nucleocapsids from the nucleus 家蚕核型多角体病毒BM61：参与病毒粒子的出核 Expression of Bombyx mori nucleopolyhedrovirus ORF76 in permissive and non-permissive cell lines by a novel Bac-to-Bac/BmNPV baculovirus expression system 利用新的Bac-to-Bac杆状病毒表达系统在敏感及非敏感细胞中表达家蚕杆状病毒的基因ORF76 Characterization of a late gene,ORF67 from Bombyx mori nucleopolyhedrovirus 家蚕核型多角体病毒晚期基因ORF67的特征分析 Characterization of Bombyx mori nucleopolyhedrovirus orf74,a novel gene involved in virulence of virus 一个家蚕核型多角体病毒毒力相关新基因orf74的鉴定 Characterization of the Bm61 of the Bombyx mori nucleopolyhedrovirus 家蚕核型多角体病毒Bm61的特征分析 Characterization of a late expression gene of Bombyx mori nucleopolyhedrovirus 家蚕核型多角体病毒晚期表达基因的表征 Bombyx mori nucleopolyhedrovirus BmP95 plays an essential role in budded virus production and nucleocapsid assembly 家蚕核型多角体病毒BmP95对于出芽型病毒粒子的产生和核衣壳的组装发挥重要作用 The formation of occlusion-derived virus is affected by the expression level of ODV-E25 ODV-E25的表达水平影响包涵体衍生型病毒粒子的形成 Bm91 is an envelope component of ODV but is dispensable for the propagation of Bombyx mori nucleopolyhedrovirus Bm91是ODV的包膜组件，但对于家蚕核型多角体病毒的繁殖是不必要的 The Bombyx mori nucleopolyhedrovirus Bm111 affects virulence but not virus replication 家蚕核型多角体病毒Bm111影响毒力，但不影响病毒的复制 BmNPV infection enhances ubiquitin-conjugating enzyme E2 expression in the midgut of BmNPV susceptible silkworm strain BmNPV感染增强BmNPV易感家蚕品系中肠内的泛素结合酶E2表达 Characterization of a protein tyrosine phosphatase as a host factor promoting baculovirus replication in silkworm,Bombyx mori 能促进家蚕杆状病毒复制的宿主因子蛋白酪氨酸磷酸酶的鉴定 Identification and characterization of the Bombyx mori myosin II essential light chain and its effect in BmNPV infection 家蚕肌球蛋白II必需轻链基因的鉴定和表征及其在BmNPV感染中的作用 Identification of a single-nucleocapsid baculovirus isolated from Clanis bilineata tsingtauica(Lepidoptera:Sphingidae) 从豆天蛾中分离到的单粒包埋型杆状病毒的鉴定 Autographa californica multiple nucleopolyhedrovirus odv-e25(Ac94)is required for budded virus infectivity and occlusion derived virus formation 苜蓿银纹夜蛾核型多角体病毒（AcMNPV）odv-e25（Ac94）是出芽型（BV）病毒感染和包涵体衍生型（ODV）病毒形成所必需 Characterization of Antheraea pernyi nucleopolyhedrovirus p11 gene,a homologue of Autographa californica nucleopolyhedrovirus orf108 苜蓿银纹夜蛾核型多角体病毒orf108的同系物，柞蚕核型多角体病毒p11基因表征研究 Reclassification of the pathogen for empty-gut disease of Chinese oak silkworm,Antheraea pernyi 柞蚕空肠病病原体重新分类 Bacillus bombysepticus α-toxin binding to G protein-coupled receptor kinase 2 regulates cAMP/PKA signaling pathway to induce host death 黑胸败血芽孢杆菌α毒素结合到G蛋白偶联受体激酶2调节cAMP/PKA信号通路诱导宿主死亡 PC,a novel oral insecticidal toxin from Bacillus bombysepticus involved in host lethality via APN and BtR-175 黑胸败血芽孢杆菌新型口服杀虫毒素通过APN和BtR-175杀死宿主 Expression of non-structural protein NS3 gene of Bombyx mori densovirus(China isolate) 家蚕二分浓核病毒（中国株）非结构蛋白NS3基因的表达 Bmpkci is highly expressed in resistant strain of silkworm(Lepidoptera:Bombycidae):implication of its role in resistance to BmDNV-Z Bmpkci在抗BmDNV品种中高水平表达预示着其在抗BmDNV-Z中发挥着重要作用 Truncation ofcytoplasmic tail of EIAV Env increases the pathogenic necrosis 贫血病毒囊膜蛋白胞内区截短增加病原性坏死 Transcriptional profiling of midgut immunity response and degeneration in the wandering silkworm,Bombyx mori 上蔟期家蚕中肠免疫反应与解离的转录组图谱 Detection and characterization of Wolbachia infection in silkworm 沃尔巴克氏体感染的家蚕检测与表征 Immune signaling pathways activated in response to different pathogenic micro-organisms in Bombyx mori 家蚕免疫信号通路对不同病原微生物的应答研究 Resistance comparison of domesticated silkworm(Bombyx mori L.)and wild silkworm(Bombyx mandarina M.)to phoxim insecticide 家蚕和野桑蚕对辛硫磷杀虫剂的抗性比较 Effects of BmCPV infection on silkworm Bombyx mori intestinal bacteria BmCPV感染对家蚕肠道菌群的影响 cDNA cloning and characterization of LASP1 from silkworm,Bombyx mori,involved in cytoplasmic polyhedrosis virus infection 家蚕LASP1基因全长cDNA的克隆及其在BmCPV感染过程中的特征分析 Microarray analysis of the gene expression profile in the midgut of silkwormi nfected with cytoplasmic polyhedrosis virus 家蚕感染质型多角体病毒后中肠基因表达谱的微阵列分析 A novel protease inhibitor in Bombyx mori is involved in defense against Beauveria bassiana 一个新的家蚕蛋白酶抑制剂参与抵御球孢白僵菌 Hindgut innate immunity and regulation of fecal microbiota through melanization in insects 昆虫通过黑化作用调节后肠先天免疫以及粪便菌群 第四章 家蚕性别调控机制研究 BmTGIF,a Bombyx mori homolog of Drosophila DmTGIF,regulates progression of spermatogenesis 果蝇DmTGIF同族体家蚕BmTGIF对精子形成过程的调节 Female qualities in males:vitellogenin synthesis induced by ovary transplants into the male silkworm,Bombyx mori 雄性的雌性特征：卵巢移植诱导雄性家蚕合成卵黄原蛋白 Vertebrate estrogen regulates the development of female characteristics in silkworm,Bombyx mori 脊椎动物雌激素调控家蚕雌性特征的发生 Proteomics analysis of adult testis from Bombyx mori 家蚕成虫精巢蛋白组学分析 The nanos gene of Bombyx mori and its expression patterns in developmental embryos and larvae tissues 家蚕的nanos基因及其在胚胎和幼虫组织中的表达模式分析 BmHrp28 is a RNA-binding protein that binds to the female-specific exon 4 of Bombyx mori dsx pre-mRNA BmHrp28是一个能与家蚕雌特异基因dsxmRNA前体第4外显子结合的RNA结合蛋白 New insights into the genomic organization and splicing of the Doublesex gene,a terminal regulator of sexual differentiation in the silkworm Bombyx mori 深入分析家蚕性别决定终端调控基因Doublesex的基因组结构和剪接形式 Novel female-specific trans-spliced and alternative splice forms of dsx in the silkworm Bombyx mori 家蚕双性基因dsx全新的雌特异反式剪接体和选择性剪接体的鉴定 Proteome analysis of silkworm,Bombyx mori,larval gonads:characterization of proteins involved in sexualdimorphism and gametogenesis 家蚕幼虫生殖腺蛋白质组分析：对性别二态性和配子形成相关蛋白的鉴定 Analysis of interaction between Bmhrp28 and BmPSI in sex-specific splicing of Bombyx mori Bmdsx gene Bmhrp28和BmPSI在家蚕Bmdsx基因的性别特异性剪接中的相互作用分析 Ectopic expression of the male BmDSX affects formation of the chitin plate in female Bombyx mori 雄蚕BmDSX基因异常表达影响雌蚕几丁质板形成 Genetic marking of sex using a W chromosome-linked transgene 使用W染色体连锁转基因进行性别遗传标记 Proteome analysis on lethal effect of l_2 in the sex-linked balanced lethal strains of silkworm,Bombyx mori 家蚕平衡致死系致死基因l2致死效应的蛋白质组分析 Proteome profiling reveals tissue-specfic protein expression in male and female accessory glands of the silkworm,Bombyx mori 家蚕蛹期雌、雄附腺特异表达蛋白的分析 Dosage analysis of Z chromosome genes using microarray in silkworm,Bombyx mori 利用芯片技术对家蚕Z染色体基因进行剂量分析 Molecular characterization and functional analysis of serine/threonine protein phosphatase of Toxocara canis 犬弓蛔虫丝氨酸/苏氨酸蛋白磷酸酶的分子特性和功能分析 第五章 蚕的遗传操作与基因编辑 Identification of a functional element in the promoter of the silkworm(Bombyx mori)fat bodyspecific gene Bmlp3 家蚕脂肪体特异基因Bmlp3启动子功能元件的鉴定 Elementary research into the transformation BmN cells mediated by the piggyBac transposon vector piggyBac转座子介导的家蚕BmN细胞转基因研究初探 Comparison of transformation efficiency of piggyBac transposon among three different silkworm Bombyx mori strains 三个不同家蚕品种中piggyBac转座子转座效率的比较分析 The relationship between internal domain sequences of piggyBac and its transposition efficiency in BmN cells and Bombyx mori piggyBac转座子内部功能域及其在BmN细胞和家蚕中的转座效率的相关分析 Postintegration stability of the silkworm piggyBac transposon piggyBac转座子整合进家蚕基因组后的稳定性分析 Remobilizing deleted piggyBac vector post-integration for transgene stability in silkworm 再转座删除piggyBac载体提高家蚕转基因稳定性研究 Advanced technologies for genetically manipulating the silkworm Bombyx mori,a model Lepidopteran insect 鳞翅目模式昆虫——家蚕的遗传改造技术前沿 Cre-mediated targeted gene activation in the middle silk glands of transgenic silkworms(Bombyx mori) Cre介导的转基因家蚕中部丝腺中的靶基因激活 Construction of transformed,cultured silkworm cells and transgenic silkworm using the site-specific integrase system from phage φC31 利用噬菌体φC31位点特异性整合酶系统构建转化培养的家蚕细胞及转基因家蚕 TAL effectors mediate high-efficiency transposition of the piggyBac transposon in silkworm Bombyx mori L. 类转录激活因子效应蛋白介导piggyBac转座子的高效转座 The clustered regularly interspaced short palindromic repeats/associated proteins system for the induction of gene mutations and phenotypic changes in Bombyx mori CRISPR/Cas9系统诱导家蚕基因突变及表型改变 Multiplex genomic structure variation mediated by TALEN and ssODN 位点特异性核酸酶TALEN和ssODN介导的多重基因组结构变异 Highly efficient and specific genome editing in silkworm using custom TALENs TALENs介导的家蚕高效特异基因组编辑 High-effciency system for construction and evaluation of customized TALENs for silkworm genome editing 适用于家蚕基因组编辑的TALENs高效系统的构建和评估 Highly efficient multiplex targeted mutagenesis and genomi cstructure variation in Bombyxmori cells using CRISPR/Cas9 运用CRISPR/Cas9实现家蚕细胞高效的多重定向诱变和基因组结构变异 Heritable genome editing with CRISPR/Cas9 in the silkworm,Bomby xmori 应用CRISPR/Cas9系统对家蚕基因组进行可遗传编辑 CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70i n Bombyx mori CRISPR/Cas9介导的家蚕多重基因组编辑与BmKu70的可遗传突变 Effects of BmKIT^R_3 gene transfer on pupal development of Bombyx moril innaeus using a Gal4/UAS binary transgenic system Gal4/UAS转基因系统表达BmKIT^R_3对家蚕蛹期发育的影响 Effects of egt gene transfer on the development of Bombyx mori 转egt基因对家蚕发育的影响 附图 家蚕功能基因组研究（下册） 封面 书名页 第六章 家蚕生物反应器研究 Development of a rapid and efficient BmNPV baculovirus expression system for application in mulberry silkworm,Bombyx mori 应用于桑叶蚕的快速有效的家蚕NPV杆状病毒表达系统的开发 Expression,purification and characterization of human GM-CSF using silkworm pupae(Bombyx mori)as a bioreactor 以家蚕蛹作为生物反应器表达、纯化和鉴定人粒细胞巨噬细胞集落刺激因子（hGM-CSF） Incorporation of partial polyhedrin homology sequences(PPHS)enhances the production of cloned foreign genes in abaculovirus expression system 部分多角体同源序列（PPHS）的整合增强杆状病毒载体系统克隆外源基因的表达 Recombinant functional human lactoferrin expressed in baculovirus system 在杆状病毒表达系统中表达功能性重组人乳铁蛋白 Expression of polyhedrin-hEGF fusion protein in cultured cells and larvae of Bombyx mori 多角体-人表皮生长因子融合蛋白在家蚕细胞及幼虫中的表达 Can 29 kDa rhGM-CSF expressed by silkworm pupae bioreactor bring into effect as active cytokine through orally administration? 蚕蛹生物反应器表达的29 kDa rhGM-CSF作为活性细胞因子能否通过口服发挥作用？ Large-scale purification of human granulocyte-macrophage colony-stimulating factor expressed in Bombyx mori pupae 人粒细胞-巨噬细胞集落刺激因子（hGM-CSF）在蚕蛹中的大规模表达纯化 Suppression of diabetes in non-obese diabetic(NOD)mice by oral administration of a cholera toxin B subunit-insulin B chain fusion protein vaccine produced in silkworm 家蚕表达的霍乱毒素B亚基-胰岛素B链融合蛋白疫苗对非肥胖糖尿病（NOD）小鼠糖尿病的口服抑制作用 Oral administration activity determination of recombinant osteoprotegerin from silkworm larvae 家蚕幼虫表达重组骨保护素的口服活性测定 Anti-oxidation and immune responses in mice upon exposure to manganese superoxide dismutase expressed in silkworm larvae,Bombyx mori L. 家蚕表达的SOD对小鼠的抗氧化和免疫反应的影响 Improvement of recombinant baculovirus infection efficiency to express manganese superoxide dismutase in silkworm larvae through dual promoters of Pph and Pp10 利用双启动子Pph与Pp10改善重组杆状病毒感染效率在家蚕幼虫中表达锰超氧化物歧化酶 The transgenic BmN cells with polyhedrin gene:a potential way to improve the recombinant baculovirus infection per os to insect larvae 携带多角体基因的转基因BmN细胞：一种提高重组杆状病毒经口感染昆虫幼虫的潜在途径 Safety and immunogenicity of H5N1 influenza vaccine based on baculovirus surface display system of Bombyx mori 基于家蚕杆状病毒表面展示系统的H5N1流感疫苗的安全性和免疫原性 High-level expression of orange fluorescent protein in the silkworm larvae by the Bac-to-Bac system 利用杆状病毒表达系统在家蚕幼虫体内高效表达橙色荧光蛋白 A novel way to purify recombinant baculoviruses by using bacmid 利用Bacmid纯化重组杆状病毒的新方法 Expression of EGFP driven by BmNPV orf4 promoter,a novel immediate early promoter 利用家蚕核型多角体病毒一个新的极早期基因orf4启动子驱动EGFP的表达 Bioavailability of orally administered rhGM-CSF:a single-dose,randomized,open-label,two-period crossover trial 口服rhGM-CSF生物利用度：单剂量、随机、开放、两期交叉临床试验 A transgenic Bm cell line of piggyBac transposon-derived targeting expression of humanized glycoproteins through N-glycosylation 利用piggyBac转座子获得表达N-糖基化的人源化糖蛋白的转基因Bm细胞系 Construction of the ie1-Bacmid expression system and its use to express EGFP and BmAGO2 in BmN cells ie1-Bacmid表达系统的构建及其在BmN细胞中表达EGFP和BmAGO2的应用 A highly efficient and simple construction strategy for producing recombinant baculovirus Bombyx mori nucleopolyhedrovirus 一种高效、简单的家蚕核型多角体病毒重组策略 Human insulin gene expressing with Bombyx mori multiple nucleopolyhedrovirus(BmMNPV)expression system 利用家蚕多核型多角体病毒（BmMNPV）表达系统表达人胰岛素基因 Cloning and expression of a cellulase gene in the silkworm,Bombyx mori by improved Bac-to-Bac/BmNPV baculovirus expression system 克隆和在家蚕中利用改进的Bac-to-Bac/BmNPV杆状病毒表达系统表达纤维素酶基因 Expression of UreB and HspA of Helicobacter pylori in silkworm pupae and identification of its immunogenicity 幽门螺杆菌尿素酶B亚基（UreB）和热休克蛋白A亚基（HspA）在蚕蛹中的表达以及其免疫原性鉴定 In vivo bioassay of recombinant human growth hormone synthesized in Bombyx mori pupae 家蚕蛹生产的重组人生长激素体内生物活性测定 Immobilization of foreign protein into polyhedra of Bombyx mori nucleopolyhedrovirus(BmNPV) 利用家蚕核型多角体病毒（BmNPV）固定外源蛋白的研究 2A self-cleaving peptide-based multi-gene expression system in the silkworm Bombyx mori 基于2A自剪切肽的家蚕多基因表达系统 The advances and perspectives of recombinant protein production in the silk gland of silkworm Bombyx mori 利用家蚕丝腺生产重组蛋白的研究进展及展望 Expression of the hGM-CSF in the silk glands of germline of gene-targeted silkworm 家蚕丝腺靶向基因hGM-CSF的表达 Lowering the blood glucose of diabetes mellitus mice by oral administration with transgenic human insulin-like growth factor I silkworms 口服转基因家蚕表达的人胰岛素生长因子I降低糖尿病小鼠的血糖 Expression of human granulocyte-macrophage colony-stimulating factor in stably-transformed BmN and Sf-9 cells and silkworms by a non-transposon vector 通过非转座子载体在稳定转化的BmN、Sf9细胞及家蚕中表达人粒细胞-巨噬细胞集落刺激因子 An optimized sericin-1 expression system for mass-producing recombinant proteins in the middle silk glands of transgenic silkworms 转基因家蚕中部丝腺中丝胶1表达系统高量表达重组蛋白的优化 Immobilization of foreign protein in BmNPV polyhedra by fusion expression with partial polyhedrin fragments 通过与部分多角体片段的融合表达将外源蛋白固定在BmNPV多角体中 Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application 通过转基因家蚕获得的先进蚕丝材料可以促进细胞增殖从而应用于生物医学领域 Reducing blood glucose levels in TIDM mice with an orally administered extract of sericin from hIGF-I-transgenic silkworm cocoons 口服hIGF-I转基因家蚕蚕茧丝胶蛋白的提取物降低TIDM小鼠血糖水平 Nonvirus encoded proteins could be embedded into Bombyx mori cypovirus polyhedra 非病毒编码的蛋白质能被包被进家蚕质型多角体 Overexpression of recombinant infectious bursal disease virus(IBDV)capsid protein VP2 in the middle silk gland of transgenic silkworm 利用转基因家蚕中部丝腺过表达重组传染性法氏囊病毒衣壳蛋白VP2 Large-scale production of bioactive recombinant human acidic fibroblast growth factor in transgenic silkworm cocoons 具有生物活性的重组人酸性成纤维细胞生长因子在转基因家蚕茧中的大规模生产 Development of a VLP-based vaccine in silkworm pupae against rabbit hemorrhagic disease virus 基于VLP进行家蚕蛹抗兔出血症病毒疫苗开发 Transgenic silkworms secrete the recombinant glycosylated MRJP1 protein of Chinese honeybee,Apis cerana cerana 转基因家蚕分泌中华蜜蜂的重组糖基化MRJP1蛋白 Analysis of the sericin1 promoter and assisted detection of exogenous gene expression efficiency in the silkworm,Bombyx mori L. 家蚕sericin1启动子的活性分析及外源基因表达的辅助检测 Expression of hIGF-I in the silk glands of transgenic silkworms and in transformed silkworm cells 转基因家蚕丝腺组织和转化家蚕细胞表达hIGF-I The promoter of Bmlp3 gene can direct fat body-specific expression in the transgenic silkworm,Bombyx mori Bmlp3启动子可以启动基因在转基因家蚕的脂肪体中特异性表达 Analysis of the activity of virus internal ribosome entry site in silkworm Bombyx mori 病毒核糖体进入位点在家蚕中的生物学活性检测 Overexpression and functional characterization of an Aspergillus niger phytase in the fat body of transgenic silkworm,Bombyx mori 黑曲霉植酸酶基因在转基因家蚕脂肪体中的表达及功能特征 Surface display of human serum albumin on Bacillus subtilis spores for oral administration 用于口服的表面展示含有人血清白蛋白重组芽孢及其制备方法 Surface display of human growth hormone on Bacillus subtilis spores for oral administration 枯草芽孢杆菌表面展示口服用人生长激素 第七章 表观遗传与miRNA Single base-resolution methylome of the silkworm reveals a sparse epigenomic map 家蚕单碱基分辨率甲基化谱揭示了一个稀疏的表观基因组图谱 Genome-wide identification of Polycomb target genes reveals a functional association of Pho with Scm in Bombyx mori 家蚕Polycomb靶基因的全基因组鉴定揭示Pho与Scm功能的相关性 Cell Cycle-Dependent Recruitment of Polycomb Proteins to the ASNS Promoter Counteracts C/ebp-Mediated Transcriptional Activation in Bombyx mori 家蚕Polycomb蛋白与C/ebp转录因子调控天冬酰胺合成酶表达的机制研究 Subcellular localization and RNA interference of an RNA methyltransferase gene from silkworm,Bombyx Mori 家蚕RNA甲基转移酶基因的亚细胞定位和RNA干扰 Comprehensive profiling of lysine acetylation suggests the widespread function is regulated by protein acetylation in the silkworm,Bombyx mori 蛋白乙酰化谱显示乙酰化修饰广泛参与调控家蚕蛋白功能 Silkworm(Bombyx mori)BmLid is a histone lysine demethylase with a broader specificity than its homolog in Drosophila and mammals 家蚕组蛋白赖氨酸去甲基化酶BmLid比其在果蝇和哺乳动物中的同源物具有更广泛的特异性 Identification and analysis of the SET-domain family in silkworm,Bombyx mori 分析鉴定家蚕的SET结构域家族 Involvement of microRNAs in infection of silkworm with Bombyx mori cytoplasmic polyhedrosis virus(BmCPV) 家蚕感染质型多角体病毒（BmCPV）相关的microRNAs Characterization and expression patterns of let-7 microRNA in the silkworm(Bomby xmori) 家蚕let-7microRNA基因的特征和表达模式 Identification and characteristics of microRNAs from Bombyx mori 家蚕microRNA的鉴定与特征 Insect-specific micro RNA involved in the development of the silkworm Bombyx mori 昆虫特异的microRNA调控家蚕的生长发育 Computational identification and characteristics of novel microRNAs from the silkworm(Bombyx mori L.) 家蚕新型microRNA的计算机鉴定及其特征 MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori MicroRNAs在家蚕多种组织中呈现多样性及动态表达模式 MicroRNAs of Bombyx mori identified by solexa sequencing 利用高通量测序鉴定家蚕中的MicroRNAs Bioinformatics analysis on structural features of microRNA precursors in insects 昆虫中microRNA前体结构特征的生物信息学分析 Expression analysis of miRNAs in BmN cells BmN细胞中miRNAs的表达分析 MicroRNA expression profiling of the fifth-instar posterior silk gland of Bombyx mori 五龄家蚕后部丝腺microRNA表达谱分析 Characterization and profiling of microRNAs in posterior silk gland of the silkworm(Bombyx mori) 家蚕幼虫后部丝腺microRNAs的鉴定与表达分析 BmNPV-miR-415 up-regulates the expression of TOR2 via Bmo-miR-5738 BmNPV-miR-415通过Bmo-miR-5738上调表达TOR2基因 Bmo-miR-2758 targets BmFMBP-1(Lepidoptera:Bombycidae)and suppresses its expression in BmN cells 家蚕miR-2758体外下调丝腺转录因子FMBP-1的表达 RIP-seq of BmAgo2-associated small RNAs reveal various types of small non-coding RNAs in the silkworm,Bombyx mori RIP-seq法鉴定BmAgo2结合小RNA揭示家蚕中多种不同类型的非编码小RNA Characterization of Argonaute family members in the silkworm,Bombyx mori 家蚕Argonaute蛋白家族成员表征 第八章 蚕的细胞生物学 Isolation and characterization of a PUF-domain of pumilio gene from silkworm Bombyx mori 家蚕pumilio基因PUF结构域的分离与鉴定 Transcriptome analysis of BmN cells following over-expression of BmSTAT 过表达BmSTAT的BmN细胞的转录组分析 BmDredd regulates the apoptosis coordinating with BmDaxx,BmCide-b,BmFadd and BmCreb in BmN cells BmDredd与BmDaxx、BmCide-b、BmFadd和BmCreb协同调控家蚕细胞的凋亡 The protein import pore Tom40 in the microsporidian Nosema bombycis 家蚕微孢子虫纺锤剩体转运蛋白NbTom40的鉴定 Hemocytes and hematopoiesis in the silkworm,Bombyx mori 家蚕血细胞与造血功能 A novel granulocyte-specific α integrin is essential for cellular immunity in the silkworm Bombyx mori 一种新的粒细胞特定整合素在家蚕细胞免疫功能中是必不可少的 A novel Lozenge gene in silkworm,Bombyx mori regulates the melanization response of hemolymph 家蚕中一种新的调节血淋巴黑化反应的Lozenge基因 Identification and characterization of three novel hemocyte-specific promoters in silkworm Bombyx mori 家蚕中三种新型血细胞特异性启动子的鉴定与表征 Characterization of hemocytes proliferation in larval silkworm,Bombyx mori 家蚕幼虫血细胞增殖特性的研究 Proteomics identification and annotation of proteins of a cell line of Bombyx mori,BmN cells. 家蚕BmN细胞系的蛋白质组学鉴定及蛋白功能注释 Establishment and characterization of two embryonic cell lines of Bombyx mori 家蚕两个胚胎细胞系的建立和表征 Establishment and characterization of an ovarian cell line of the silkworm,Bombyx mori 家蚕卵巢细胞系的建立与鉴定 Existence of prophenoloxidase in wing discs:a source of plasma prophenoloxidase in the silkworm,Bombyx mori 翅原基中存在酚氧化酶：家蚕血淋巴中酚氧化酶的来源 Characterization and identification of the integrin family in silkworm,Bombyx mori 家蚕整合素家族的表征及鉴定 Cloning and analysis of DnaJ family members in the silkworm,Bombyx mori 家蚕DnaJ家族成员的克隆与分析 Establishment and characterization of a new embryonic cell line from the silkworm,Bombyx mori 一个新的家蚕胚胎细胞系的建立与鉴定 Agkistin-s,a disintegrin domain,inhibits angiogenesis and induces BAECs apoptosis 蛇毒金属蛋白酶去整合素结构域agkistin-s抑制血管生成并诱导BAECs凋亡 第九章 家蚕突变体分子机理研究 The scaleless wings mutant in Bombyx mori is associated with a lack of scale precursor cell differentiation followed by excessive apoptosis 家蚕翅无鳞毛突变体与鳞片前体细胞分化不足及随后的过度凋亡有关 Proteomic analysis of the phenotype of the scaleless wings mutant in the silkworm,Bombyx mori 家蚕翅无鳞毛突变体表型的蛋白质组学分析 Cloning,expression and enzymatic properties analysis of dihydrofolate reductase gene from the silkworm,Bombyx mori 家蚕二氢叶酸还原酶基因的克隆、表达及酶学特征分析 Effects of altered catecholamine metabolism on pigmentation and physical properties of sclerotized regions in the silkworm melanism mutant 改变儿茶酚胺代谢对蚕黑色素突变体的色素沉积和物理性质的影响 Isolation,purification,and identification of an important pigment,sepiapterin,from integument of the lemon mutant of the silkworm,Bombyx mori 家蚕lemon突变体表皮中重要色素墨蝶呤的分离、纯化和鉴定 Transcriptome analysis of neonatal larvae after hyperthermia-induced seizures in the contractile silkworm,Bombyx mori 高温诱导癫痫缩蚕的初生幼虫的转录组分析 Transcriptome analysis of integument differentially expressed genes in the pigment mutant(quail)during molting of silkworm,Bombyx mori 家蚕蜕皮过程中色素突变体（quail）表皮差异表达基因的转录组分析 Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori 家蚕四氢生物蝶呤再生途径中的两种酶BmPCD和BmDHPR的分子及酶学特征分析 Comparativ eanalysis of the integument transcriptomes of the black dilute mutant and the wild-type silk worm Bombyx mori 淡墨突变体和野生型家蚕的表皮转录组比较分析 Linkage and mapping analyses of the densonucleosis non-susceptible gene nsd-Z in the silkworm Bombyx mori using SSR markers 利用SSR标记对导致家蚕浓核病的非易感基因nsd-Z进行连锁图谱分析 Detection of homozygosity in near isogenic lines of non-susceptible to Zhenjiang strain of densonucleosis virus in silkworm 家蚕浓核病毒（镇江株）不敏感近等基因系的纯合性检测 Linkage analysis of the visible mutations Sel and Xan of Bombyx mori(Lepidoptera:Bombycidae)using SSR markers 利用SSR标记对家蚕（鳞翅目：蚕蛾科）Sel和Xan基因进行连锁分析 SSR based linkage and mapping analysis of C,a yellow cocoon gene in the silkworm,Bombyx mori 利用SSR法对家蚕黄茧基因C进行连锁定位分析 Fine mapping of E^(kp)-1,a locus associated with silkworm(Bombyx mori)proleg development 家蚕腹足发育相关基因座E^(kp)-1的精细定位 Fine mapping of a supernumerary proleg mutant(E^(C_s)-l)and comparative expression analysis of the abdominal-A gene in silkworm,Bombyx mori 家蚕E^(C_s)-l突变体的精细定位以及家蚕abd-A基因的比较表达分析 Molecular mapping and characterization of the silkworm apodal mutant 家蚕apodal突变体的分子定位与鉴定 A composite method for mapping quantitative trait loci without interference of female achiasmatic and gender effects in silkworm,Bombyx mori 一种不影响蚕蛾雌性性别的用于定位数量性状基因座的复合方法 Mutations of an Arylalkylamine-N-acetyl transferase,Bm-iAANAT,are responsible for silkworm melanism mutant 芳烷基胺-N-乙酰转移酶基因Bm-iAANAT突变导致家蚕黑化突变体的产生 Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation 家蚕N-乙酰转移酶基因的功能缺失揭示其在色素沉积中的新作用 Repression of tyrosine hydroxylase is responsible for the sex-linked chocolate mutation of the silkworm,Bombyx mori 抑制酪氨酸羟化酶引起家蚕伴性遗传巧克力色突变体产生 Vitellogenin receptor mutation leads to the oogenesis mutant phenotype“scanty vitellin”of the silkworm,Bombyx mori 家蚕卵黄原蛋白受体（BmVgR）突变导致卵子发生突变体“scanty vitellin”（vit）的形成 Mutation of a vitelline membrane protein,BmEP80,is responsible for the silkworm“Ming”lethal egg mutant 卵黄膜蛋白BmEP80突变是导致家蚕“Ming”卵致死的原因 Mutation of a cuticular protein,BmorCPR2,alters larval body shape and adaptability in silkworm,Bombyx mori 家蚕表皮蛋白BmorCPR2的突变改变家蚕幼虫的体形及适应性 Functional loss of Bmsei causes thermosensitive epilepsy in contractile mutant silkworm,Bombyx mori 家蚕缩蚕突变体中Bmsei功能缺失引起热敏性癫痫 Silkworms can be used as an animal model to screen and evaluate gouty therapeutic drugs 家蚕可作为筛选和评估痛风治疗药物的动物模型 第十章 家蚕蛋白质组研究 Identification of the proteome of the midgut of silkworm,Bombyx mori L.,by multidimensional liquid chromatography(MDLC)LTQ-Orbitrap MS 利用多维液相色谱（MDLC）LTQ-Orbitrap质谱鉴定家蚕中肠蛋白质组 Shotgun proteomics approach to characterizing the embryonic proteome of the silkworm,Bombyx mori,at labrum appearance stage 鸟枪法蛋白质组学方法分析上唇突显期的家蚕胚胎 Shotgun proteomic analysis of the fat body during metamorphosis of domesticated silkworm(Bombyx mori) 家蚕变态期脂肪体的蛋白质组分析 Shotgun proteomic analysis on the embryos of silkworm Bombyx mori at the end of organogenesis 鸟枪法分析组织发生末期的家蚕胚胎蛋白质组 Shotgun proteomic analysis of wing discs from the domesticated silkworm(Bombyx mori)during metamorphosis 家蚕变态发育过程中翅原基的蛋白质组学分析 Proteome analysis on differentially expressed proteins of the fat body of two silkworm breeds,Bombyx mori,exposed to heat shock exposure 家蚕不同品种在热激处理下的脂肪体蛋白质组学分析 Application of proteomic technology in silkworm research 蛋白质组学在家蚕研究中的应用 Proteomic and bioinformatic analysis on endocrine organs of domesticated silkworm,Bombyx mori L.for a comprehensive understanding of their roles and relations 蛋白质组学和生物信息学分析家蚕内分泌器官的功能及其关系 Proteomic identification of the silkworm(Bombyx mori L.)prothoracic glands during the fifth instar stage 家蚕五龄幼虫前胸腺蛋白组鉴定 Shotgun strategy-based proteome profiling analysis on the head of silkworm Bombyx mori 基于鸟枪法策略的家蚕头部蛋白质组分析 Proteomic profiling of the hemolymph at the fifth instar of the silkworm Bombyx mori 家蚕五龄期血淋巴蛋白质组分析 Proteomic analysis of peritrophic membrane(PM)from the midgut of fifth-instar larvae,Bombyx mori 家蚕五龄幼虫中肠围食膜的蛋白质组分析 Proteomic-based insight into malpighian tubules of silkworm Bombyx mori 家蚕马氏管蛋白质组学研究 Comparative proteomic analysis reveals the suppressive effects of dietary high glucose on the midgut growth of silkworm 比较蛋白质组学分析揭示摄食高葡萄糖对蚕中肠生长的抑制作用 Development of an effective sample preparation approach for proteomic analysis of silkworm eggs using two-dimensional gel electrophoresis and mass spectrometry 5用于双向电泳和质谱检测的蚕卵蛋白质高效样品制备方法开发 Shotgun analysis on the peritrophic membrane of the silkworm Bombyx mori 家蚕围食膜“鸟枪法”蛋白质组学分析 Comparative proteomic analysis between the domesticated silkworm(Bombyx mori)reared on fresh mulberry leaves and on artificial diet 新鲜桑叶和人工饲料饲养的家蚕间的比较蛋白质组学研究 Shotgun proteomic analysis of Bombyx mori brain:emphasis on regulation of behavior and development of the nervous system 鸟枪法蛋白质组分析家蚕脑组织：着重于行为的调控以及神经系统发育 Proteomic analysis of the silkworm(Bombyx mori L.)hemolymph during developmental stage 家蚕不同发育阶段血淋巴蛋白质组学分析 Proteomics of larval hemolymph in Bombyx mori reveals various nutrient-storage and immunityrelated proteins 家蚕幼虫血淋巴蛋白质组学揭示各种营养储存和免疫相关蛋白 Determination of protein composition and host-derived proteins of Bombyx mori nucleopolyhedrovirus by2-dimensional electrophoresis and mass spectrometry 通过二维电泳和质谱法检测家蚕核型多角体病毒的蛋白质组成及宿主来源的蛋白质的分析 Comparative proteomic analysis reveals that caspase-1 and serine protease may be involved in silkworm resistance to Bombyx mori nuclear polyhedrosis virus 比较蛋白质组学分析显示半胱天冬酶-1和丝氨酸蛋白酶可能参与了家蚕对家蚕核型多角体病毒的抗性 Proteomics analysis of digestive juice from silkworm during Bombyx mori nucleopolyhedrovirus infection 感染核型多角体病毒后家蚕消化液的蛋白质组学分析 Analysis of protein expression patterns of silkworm Jinqiu and its cross parents 家蚕“金秋”及其亲本之间的蛋白表达模式分析 A novel droplet-tap sample-loading method for two-dimensional gel electrophoresis 一种新的二维凝胶电泳液滴取样加载方法 第十一章 蚕的进化与比较基因组 Complete resequencing of 40 genomes reveals domestication events and genes in silkworm(Bombyx mori L) 40个基因组完全重测序揭示蚕的驯化事件及相关基因 A dvances in silkworm studies accelerated by the genome sequencing of Bombyx mori 家蚕基因组测序加速了家蚕研究的进展 Genetic diversity,molecular phylogeny and selection evidence of the silkworm mitochondria implicated by complete resequencing of 41 genomes 通过41个线粒体基因组的完全重测序对家蚕线粒体进行遗传多样性、分子系统发生和选择进化分析 Genome-wide patterns of genetic variation among silkworms 家蚕全基因组遗传变异模式 The complete mitogenome and phylogenetic analysis of Bombyx mandarina strain Qingzhou 野桑蚕青州品系的线粒体基因组序列和系统发育分析 A genetic diversity study of silkworm using cleaved amplified polymorphic sequence(CAPS)markers 利用酶切扩增多态序列（CAPS）进行家蚕遗传多样性分析 Evolutionarily conserved repulsive guidance role of Slit in the silkworm Bombyx mori 家蚕Slit在进化上保守的排斥导向作用 Analyzing genetic relationships in Bombyx mori using intersimple sequence repeat amplification 利用简单重复扩增序列分析家蚕不同品系之间的遗传关系 Gene analysis of anantiviral protein SP-2 from Chinese wild silkworm,Bombyx mandarina Moore and its bioactivity assay 中国野桑蚕抗病毒蛋白SP-2的序列分析及其生物活性测定 Comparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation 家蚕微孢子虫的比较基因组学显示基因组扩增与宿主适应之间的关联 The varying microsporidian genome:existence of long-terminal repeat retrotransposon in domesticated silkworm parasite Nosema bombycis 不同微孢子虫基因组：家蚕微孢子虫中存在长末端重复逆转录转座子 Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts 杆状病毒和昆虫宿主泛素基因的进化分析 Characterization of mitochondrial genome of Chinese wild mulberry silkworm,Bombyx mandarina(Lepidoptera:Bombycidae) 中国野桑蚕线粒体基因组特征 An integrated genetic linkage map for silkworms with three parental combinations and its application to the mapping of single genes and QTL 家蚕三亲本组合遗传连锁图谱及其在单基因和QTL定位中的应用 The genome of a lepidopteran model insect,the silkworm Bombyx mori 鳞翅目模式昆虫家蚕的基因组 Molecular determinants and evolutionary dynamics of wobble splicing 摆动剪接的分子决定因素和进化动力学 A-to-I editing sites are a genomically encoded G:Implications for the evolutionary significance and identification of novel editing sites A-to-I编辑位点是基因组编码的G：对新的编辑位点和进化意义的启示 A-to-I RNA editing alters less-conserved residues of highly conserved coding regions:Implications for dual functions in evolution A-to-IRNA编辑改变高度保守编码区的不保守氨基酸残基：在进化中的双重功能提示 Complete sequence and organization of Antheraea pernyi nucleopolyhedrovirus,a dr-rich baculovirus 柞蚕核型多角体病毒的全基因组序列和组成，一种富含dr区的杆状病毒 Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm,Bombyx mori 家蚕不同组织中基因表达特征的生物芯片研究 From genome to proteome:great progress in the domesticated silkworm(Bombyx mori L.) 从基因组到蛋白质组：家蚕重大进展 Reference genes identified in the silkworm Bombyx mori during metamorphism based on oligonucleotide microarray and confirmed by qRT-PCR 基于家蚕芯片及荧光定量PCR技术对家蚕表达发育时期看家基因的鉴定与筛选 In silico identification of silkworm selenoproteomes 家蚕硒蛋白组的计算机识别 Aligning the proteome and genome of the silkworm,Bombyx mori 家蚕的蛋白质组和基因组比较 Transcriptome sequencing and positive selected genes analysis of Bombyx mandarina 野蚕转录组测序和正向选择基因的分析 The complete mitochondrial genome of the Chinese oak silkmoth,Antheraea pernyi(Lepidoptera:Saturniidae) 中国柞蚕完整线粒体基因组 RNA recognition motif(RRM)-containing proteins in Bombyx mori 家蚕RNA识别结构域富含蛋白鉴定 A genomewide survey of homeobox genes and identification of novel structure of the Hox cluster in the silkworm,Bombyx mori 家蚕同源异型盒基因的全基因组检测以及家蚕Hox基因新结构的鉴定 SilkDB v2.0:a platform for silkworm(Bombyx mori)genome biology SilkDB v2.0：家蚕（Bombyxmori）基因组生物学平台 Genomic sequence,organization and characteristics of a new nucleopolyhedrovirus isolated from Clanis bilineata larva 从豆天蛾幼虫分离出的新的核型多角体病毒的基因组序列、组成和特征 Gene expression divergence and evolutionary analysis of the drosomycin gene family in Drosophila melanogaster 黑腹果蝇drosomycin基因家族的基因表达差异与进化分析 BmSE,a SINE family with 3′ends of(ATTT)repeats in domesticated silkworm(Bombyx mori) BmSE，一个具有（ATTT）3′端重复的SINE家族 Identification of novel members reveals the structural and functional divergence of lepidopteranspecific Lipoprotein_11 family Lipoprotein_11家族新成员的鉴定揭示了鳞翅目特异性Lipoprotein_11的结构和功能差异 Genome-wide analysis of the WW domain-containing protein genes in silkworm and their expansion in eukaryotes 全基因组分析家蚕中含有WW结构域的蛋白质基因及其在真核生物中的扩增 Nuclear receptors in Bombyx mori:Insights into genomic structure and developmental expression 家蚕核受体基因结构和表达分析 The genomic underpinnings of apoptosis in the silkworm,Bombyx mori 家蚕细胞凋亡的基因组基础分析 Transcriptome analysis of the silkworm(Bombyx mori)by high-throughput RNA sequencing 通过高通量测序技术对家蚕的转录组进行分析 Genome-wide comparison of genes involved in the biosynthesis,metabolism,and signaling of juvenile hormone between silkworm and other insects 全基因组比较分析家蚕和其他昆虫中参与保幼激素生物合成、代谢和信号传导的基因 In silico identification of BESS-DC genes and expression analysis in the silkworm,Bombyx mori 家蚕BESS-DC基因的生物信息学鉴定与表达分析 Identification and characterization of the cyclin-dependent kinases gene family in silkworm,Bombyx mori 鉴定并分析家蚕细胞周期蛋白依赖性蛋白激酶基因家族 Identification and analysis of YELLOW protein family genes in the silkworm,Bombyx mori 家蚕YELLOW蛋白家族基因的鉴定与分析 Identification and expression pattern of the chemosensory protein gene family in the silkworm,Bombyx mori 家蚕化学感受蛋白基因家族的鉴定和表达特征分析 Analysis of the structure and expression of the 30Kprotein genes in silkworm,Bombyx mori 家蚕30K蛋白基因的结构和表达分析 Species-specific expansion of C2H2 zinc-finger genes and their expression profiles in silkworm,Bombyx mori 家蚕C2H2型锌指蛋白基因物种特异性扩增及表达谱分析 Characterization of multiple CYP9A genes in the silkworm,Bombyx mori 家蚕多个CYP9A基因的特征分析 Identification and analysis of Toll-related genes in the domesticated silkworm,Bombyx mori 家蚕Toll相关基因的鉴定和分析 Identification of MBF2 family genes in Bombyx mori and their expression in different tissues and stages and in response to Bacillus bombysepticus infection and starvation 家蚕MBF2家族基因的鉴定及其在不同组织和时期的表达以及对家蚕饥饿和黑胸败血芽孢杆菌的应答反应 Identification and characterization of piggyBac-like elements in the genome of domesticated silkworm,Bombyx mori 家蚕基因组中piggyBac类似转座元件的鉴定和描述 The UDP-glucosyltransferase multigene family in Bombyx mori 家蚕尿苷二磷酸-糖基转移酶多基因家族的分析 Annotation and expression of carboxylesterases in the silkworm,Bombyx mori 家蚕羧酸酯酶的注释和表达 Genome-wide identification and characterization of ATP-binding cassette transporters in the silkworm,Bombyx mori 家蚕基因组中ATP结合转运蛋白的鉴定与描述 Genome-wide analysis of the ATP-binding cassette(ABC)transporter gene family in the silkworm,Bombyx mori 家蚕ATP结合盒（ABC）转运蛋白基因家族的全基因组分析 Genome-wide identification and expression profiling of the fatty acid desaturase gene family in the silkworm,Bombyx mori 家蚕脂肪酸脱氢酶基因家族的全基因组鉴定和表达谱分析 Characters and expression of the gene encoding DH,PBAN and other FXPRLamide family neuropeptides i nAntheraea pernyi 柞蚕中编码DH、PBAN和其他FXPRLamide家族神经肽的基因的特征和表达 Transcriptome analysis of the brain of the silkworm Bombyx mori infected with Bombyx mori nucleopolyhedrovirus:a new insight into the molecular mechanism of enhanced locomotor activity induced by viral infection 感染BmNPV后家蚕脑的转录组分析：病毒感染诱导宿主运动增强行为的分子机制 Analysis of oral infection and helicase gene of the nucleopolyhedroviruses isolated from Philosamia cynthia ricini and Antheraea pernyi 比较分析蓖麻蚕和柞蚕核型多角体病毒的经口感染途径及解旋酶基因 The odorant binding protein gene family from the genome of silkworm,Bombyx mori 家蚕基因组中的气味结合蛋白基因家族的分析 The basic helix-loop-helix transcription factor family in Bombyx mori 家蚕碱性螺旋-环-螺旋（bHLH）转录因子家族分析 Identification and characterization of 30K protein genes found in Bombyx mori(Lepidoptera:Bombycidae)transcriptome 家蚕转录组中30K蛋白基因的鉴定与表征 A genome-wide survey for host response of silkworm,Bombyx mori during pathogen Bacillus bombyseptieus infection 家蚕对病原细菌黑胸败血菌的全基因组水平的应答调查 Immunoglobulin superfamily is conserved but evolved rapidly and is active in the silkworm,Bombyx mori 家蚕免疫球蛋白超家族基因的保守性、快速进化及活化特征分析 Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori 家蚕丝氨酸蛋白酶和同系物的全基因组鉴定和表达分析 Genome-wide identification and immune response analysis of serine protease inhibitor genes in the silkworm,Bombyx mori 家蚕体内丝氨酸蛋白酶抑制剂的全基因组鉴定与免疫反应分析 Bombyx mori transcription factors:genome-wide identification,expression profiles and response to pathogens by microarray analysis 通过基因芯片数据对家蚕转录因子进行全基因组鉴定、表达谱分析和响应病原菌感染分析 Genome-wide transcriptional response of silkworm(Bombyx mori)to infection by the microsporidian Nosema bombycis 家蚕微孢子虫诱导家蚕全基因组转录应答 Genome-wide identification and comprehensive analyses of the kinomes in four pathogenic microsporidia species 全基因组鉴定和综合分析四种致病性微孢子虫的蛋白激酶组 第十二章 素材创制与品种培育 The progress and future of enhancing antiviral capacity by transgenic technology in the silkworm Bombyx mori 家蚕转基因抗病毒研究进展与展望 Selection of reference genes for analysis of stress-responsive genes after challenge with viruses and temperature changes in the silkworm Bombyx mori 家蚕受病毒和高温胁迫后对应激反应基因进行分析的家蚕内参基因的筛选 Suppression of intestinal immunity through silencing of TCTP by RNAi intransgenic silkworm,Bombyx mori 通过转基因干涉家蚕肠道TCTP抑制肠道免疫 TIL-type protease inhibitors may be used as targeted resistance factors to enhance silkworm defenses against invasive fungi TIL型蛋白酶抑制剂可作为靶标抗性因子增强家蚕对入侵真菌的防御 Overexpression of host plant urease in transgenic silkworms 家蚕中转基因过表达宿主植物脲酶的研究 Differentially expressed genes in the midgut of silkworm infected with cytoplasmic polyhedrosis virus 家蚕感染质型多角体病毒后中肠基因的差异表达分析 Cytoplasmic polyhedrosis virus-induced differential geneexpression in two silkworm strains of different susceptibility 两个不同抗性家蚕品种感染BmCPV的差异表达基因分析 Digital gene expression analysis in the midgut of 4008 silkworm strain infected with cytoplasmic polyhedrosis virus 家蚕品种4008感染BmCPV的数字基因表达谱分析 Transcriptome analysis of interactions between silkworm and cytoplasmic polyhedrosis virus 转录组分析家蚕和质型多角体病毒的相互作用 Cloning and expression analysis of a peptidoglycan recognition protein in silkworm related to virus infection 家蚕感染病毒相关的肽聚糖识别蛋白的克隆与表达分析 dsRNA interference on expression of a RNA-dependent RNA polymerase gene of Bombyx mori cytoplasmic polyhedrosis virus dsRNA干扰家蚕质型多角体病毒RNA依赖型的RNA聚合酶基因的表达 Transgenic breeding of anti-Bombyx mori L.nuclear polyhedrosis virus silkworm Bombyx mori 通过转基因技术培育抗核型多角体病毒的家蚕 V-ATPase is involved in silkworm defense response against Bombyx mori nucleopolyhedrovirus V-ATP酶涉及家蚕对家蚕核型多角体病毒的防御反应 Identification of a new sprouty protein responsible for the inhibition of the Bombyx mori nucleopolyhedrovirus reproduction 一种抑制家蚕核型多角体病毒复制的新蛋白Sprouty的鉴定 Resistance to Bombyx mori nucleopolyhedrovirus via overexpression of an endogenous antiviral gene in transgenic silkworms 增量表达内源抗病毒基因提高转基因家蚕对核型多角体病毒的抗性 Resistance to BmNPV via overexpression of an exogenous gene controlled by an inducible promoter and enhancer in transgenic silkworm,Bombyx mori 诱导型启动子和增强子介导外源基因的增量表达提高转基因家蚕对BmNPV的抗性 Comparison of factors that may affect the inhibitory efficacy of transgenic RNAi targeting of baculoviral genes in silkworm,Bombyx mori 家蚕杆状病毒转基因干涉抑制效果影响因素的比较 Short hairpin RNA expression for enhancing the resistance of Bombyx mori(Bm)to nucleopolyhedrovirus in vitro and in vivo 过表达短发夹RNA增强体外和体内家蚕对BmNPV抗性 Resistance of transgenic silkworm to BmNPV could be improved by silencing ie-1 and lef-1 genes 通过沉默ie-1和lef-1基因可以提高转基因家蚕对BmNPV的抗性 piggyBac transposon-derived targeting shRNA interference against the Bombyx mori nucleopolyhedrovirus(BmNPV) 基于piggyBac转座子系统靶向shRNA干涉抵抗家蚕核型多角体病毒（BmNPV） Identification of a midgut-specific promoter in the silkworm Bombyx mori 家蚕中肠特异启动子的鉴定 A transgenic animal with antiviral properties that might inhibit multiple stages of infection 在感染的多个阶段抑制病毒的转基因动物 Molecular cloning and characterization of a putative cDNA encoding endoglucanase IV from Trichoderma viride and its expression in Bomby xmori 编码绿色木霉内切葡聚糖酶IV的假定cDNA的分子克隆和鉴定及其在家蚕中的表达 第十三章 其他研究 N-terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease 家蚕丝素的N端结构域介导了蚕丝的组装以响应pH值的降低 Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin 18 从结构上分析家蚕蛋白酶抑制剂serpin 18的独特抑制机制 Crystal structure of Bombyx mori arylphorins reveals a 3:3 heterohexamer with multiple papain cleavage sites 家蚕贮藏蛋白晶体结构显示其为含有多个木瓜蛋白酶酶切位点的3∶3六聚体 Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori 家蚕保幼激素环氧水解酶的晶体结构 Crystal structure of the 30K protein from the silkworm Bombyx mori reveals a new member of the beta-trefoil superfamily 家蚕30K蛋白是β三叶草家族中的一个新成员 Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx moriand the implications in amyotrophic lateral sclerosis 家蚕Cu/Zn-SOD全酶及其无铜晶体结构及其对肌萎性脊髓侧索硬化症的提示 Crystal structure of Bombyx mori nucleopolyhedrovirus ORF75 reveals a pseudo-dimer of thiol oxidase domains with a putative substrate-binding pocket 家蚕核型多角体病毒ORF75蛋白的晶体结构揭示该蛋白是一个拥有硫基氧化酶底物结合口袋结构域的假二聚体 Cloning and homologic analysis of Tpn I gene in silkworm Bombyx mori 家蚕TpnI基因的克隆和同源性分析 Cloning and characterization of hydroxypyruvate isomerase(EC 5.3.1.22)gene in silkworm Bombyx mori 家蚕中羟基丙酮酸异构酶（EC5.3.1.22）基因的克隆和表征 Molecular characters and expression analysis of the gene encoding eclosion hormone from the Asian corn borer,Ostrinia furnacalis 亚洲玉米螟编码羽化激素基因的分子特征和表达分析 Transcription level of messenger RNA per gene copy determined with dual-spike-in strategy 双跟踪策略确定每个基因拷贝的信使RNA转录水平 Identification and characterization of an arginine kinase as a major allergen from silkworm(Bombyx mori)larvae 家蚕主要过敏原精氨酸激酶的鉴定和表征 Genotyping of acetylcholinesterase in insects 昆虫乙酰胆碱酯酶的基因分型 Molecular cloning,expression and characterization of BmIDGF gene from Bombyx mori 家蚕BmIDGF基因的分子克隆、表达和表征 Structure-guided activity restoration of the silkworm glutathione transferase Omega GSTO3-3 家蚕谷胱甘肽转移酶OmegaGSTO3-3的结构诱导的活性恢复 A syntenic coding region for vitelline membrane proteins in four lepidopteran insects 卵黄膜蛋白在四个鳞翅目昆虫中的同义编码区域 Molecular characterization of a peritrophic membrane protein from the silkworm,Bombyx mori 一种家蚕围食膜蛋白的分子表征 A novel method of silkworm embryo preparation for immunohistochemistry 一种制备家蚕胚胎用于免疫组织化学实验的新方法 Expression analysis of chlorophyllid α binding protein,a secretory,red fluorescence protein in the midgut of silkworm,Bombyx mori 家蚕中肠红色荧光分泌蛋白叶绿酸α结合蛋白CHBP的表达分析 Molecular cloning and characterization of a Bombyx mori gene encoding the transcription factor Atonal 家蚕基因编码转录因子Atonal的分子克隆和特征分析 BmHSP20.8 is localized in the mitochondria and has a molecular chaperone function in vitro BmHSP20.8蛋白定位于线粒体并具有分子伴侣功能 Expression analysis and tissue distribution of two 14-3-3 proteins in silkworm(Bombyx mori) 家蚕中两种14-3-3蛋白的表达分析和组织分布 Expression analysis and characteristics of profilin gene from silkworm,Bombyx mori 家蚕profilin基因的表达和特征分析 Expression analysis and characteristics of Bm-LOC778477 gene,a hypothetical protein from silkworm pupae,Bombyx mori 家蚕蚕蛹中假定蛋白基因Bm-LOC778477的表达分析和特征 Cloning and partial characterization of a gene in Bombyx mori homologous to a human adiponectin receptor 家蚕脂联素受体同源基因的克隆和功能初探 Identification and characterization of a novel 1-Cys peroxiredoxin from silkworm,Bombyx mori 一个新的家蚕1-Cys过氧化物氧还蛋白的鉴定和功能分析 Cloning and characterization of the gene encoding an ubiquitin-activating enzyme E1domaincontaining protein of silkworm,Bombyx mori 编码家蚕含E1蛋白结构域的泛素活化酶基因的克隆与鉴定 Cloning,expression,and cell localization of a novel small heat shock protein gene:BmHSP25.4 一个新的小热激蛋白基因BmHSP25.4的克隆、表达和细胞定位 Molecular cloning and expression analysis of Bmrbp1,the Bombyx mori homologue of the Drosophila gene rbp1 家蚕中果蝇的同源基因Bmrbp1的分子克隆和表达分析 Structure characteristics and expression profiles of Bombyx mori α1(Ⅳ)collagen gene,a temperature-sensitive lethality-related gene 家蚕Ⅳ型胶原蛋白质（ColⅣ）基因的结构特征与表达谱分析 Molecular characterization and tissue localization of an F-Box only protein from silkworm,Bombyx mori 家蚕F-box蛋白的分子鉴定与组织定位 Characterization of the gene BmEm4,a homologue of Drosophila E(spl)m4,from the silkworm,Bombyx mori 家蚕中果蝇E（spl）m4同源基因BmEm4的特征 Identification and functional characterization of the Rad23 gene of the silkworm,Bombyx mori 家蚕Rad23基因的鉴定和功能特征 All-trans retinoic acid affects subcellular localization of a novel BmNIF3l protein:functional deduce and tissue distribution of NIF3l gene from silkworm(Bombyx mori) 全反式维甲酸对家蚕BmNIF3l蛋白亚细胞定位的影响：BmNIF3l基因的功能演绎以及组织分布研究 Purification,characterization and cloning of a chymotrypsin inhibitor(CI-9)from the hemolymph of the silkworm,Bombyx mori 家蚕血淋巴糜蛋白酶抑制剂（CI-9）的纯化、表征和克隆 Characterization and localization of the vacuolar-type ATPase in the midgut cells of silkworm(Bombyx mori) 家蚕中肠细胞V型ATPase的表征和定位分析 Molecular cloning and characterization of Bombyx mori sterol carrier protein x/sterol carrier protein2(SCPx/SCP2)gene 家蚕甾醇转运蛋白SCPx/SCP2基因的克隆与分析 Expression and functional analysis of the cellular retinoic acid binding protein from silkworm pupae(Bombyx mori) 蚕蛹细胞维甲酸结合蛋白的表达和功能分析 Comparisons of contact chemoreception and food acceptance by larvae of polyphagous Helicoverp aarmigera and oligophagous Bombyx mori 杂食性棉铃虫和寡食性家蚕幼虫接触化学感应和食物接受的比较 Microbial communities in the larval midgut of laboratory and field populations of cotton bollworm(Helicoverpa armigera) 棉铃虫实验室和田间种群幼虫中肠微生物群落研究 A novel method for isolation of membrane proteins:a baculovirus surface display system 一种分离膜蛋白的新方法：杆状病毒表面展示系统 Analysis of similarity/dissimilarity of DNA sequences based on a class of 2D graphical representation 基于一类二维图形表示的DNA序列相似性/相异性分析 Analysis of similarity/dissimilarity of protein sequences 蛋白质序列相似性/相异性分析 Effect of extracts of mulberry leaves processed differently on the activity of α-glucosidase 不同加工方法的桑叶提取物对α-糖苷酶活性的影响 Bactrocerin-1:a novel inducible antimicrobial peptide from pupae of oriental fruit fly Bactrocera dorsalis Hendel 一种来自桔小实蝇蛹的新诱导型抗菌肽 Molecular and functional characterization of a c-type lysozyme from the Asian corn borer,Ostrinia furnacalis 一种亚洲玉米螟（Ostrinia furnacalis）溶菌酶的分子特征及其功能表征 附图 封底 ..更多